RIG-I-Like Receptors: One STrEP Forward
Trends in Microbiology, Volume 24, Issue 7, p517–519, DOI: http://dx.doi.org/10.1016/j.tim.2016.05.001
Trends in Microbiology, online article
RIG-I-like receptors detect cytosolic viral RNA and activate an antiviral innate immune response. A new study employs the one STrEP-purification technique and next generation sequencing to characterize physiological ligands in an infected cell. The view of all three RLRs bound to viral RNAs shows specialization, collaboration and new binding sites.